Hypertension
and Vascular Research Division
Department
of Medicine
Henry Ford Hospital
2799 West Grand Blvd.
Detroit, Michigan 48202
Senior
Staff Scientists
Oscar
A. Carretero, M.D., Division Head (ocarret1@hfhs.org)
William
H. Beierwaltes, Ph.D. (wbeierw1@hfhs.org)
Jeffrey
L. Garvin, Ph.D. (jgarvin1@hfhs.org)
Pamela Harding, Ph.D.
(phardin1@hfhs.org)
Margot C.
LaPointe, Ph.D. (mlapoin1@hfhs.org)
Pablo Ortiz, Ph.D.
(portiz1@hfhs.org)
Patrick
J. Pagano, Ph.D. (ppagano1@hfhs.org)
Nour-Eddine
Rhaleb, Ph.D. (nrhaleb1@hfhs.org)
Ed
Shesely, Ph.D. (eshesel1@hfhs.org)
Xiao-Ping
Yang, M.D. (xpyang1@hfhs.org)
Jia L. “Joe” Zhuo, M.D., Ph.D. (jzhuo1@hfhs.org)
Our program of basic biomedical research seeks to understand:
1.
The
role of vasoconstrictors and vasodilators (angiotensin II, bradykinin, nitric oxide,
natriuretic peptides) in the regulation of blood pressure, development of
hypertension, and development of target organ damage (myocardial infarction,
heart failure, vascular injury, and renal disease);
2. The generation of reactive oxygen species by
blood vessels and kidney cells, and how this contributes to target organ
damage; and
3. The mechanisms by which therapeutic agents
such as angiotensin-converting enzyme inhibitors (ACEi), Ac-SDKP, and angiotensin
II type I (AT1) receptor antagonists provide protection.
We utilize state-of-the-art techniques such as molecular biology, cell
biology, microdissection of kidney tubules and arterioles, cell culture,
whole-animal physiology, and knockout and transgenic mouse models.
Facilities